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I've stored all of my client's purchased jpeg files, proofs and current working files on there. Clients know that there files are on record for one year, so the plan is every 4 months to clear out any files that are more than a year old. I will still have a DVD copy of any files over a year old at both my home and my mother's home, so no need to keep older files on MobileMe for more than a year. For $99 a year, you you get 20GB, not a bad deal at all. For an extra $49 a year you can store 40GB and 60GB for an additional $99. So if I get to the point where I know I'll be storing more than 20GB, I'll have additional options.
Hopefully I'll my system won't crash or my house destroyed by natural disaster, but just in case, it's nice to know that all my current client files, as well as my forms, actions and other purchased files are backed-up online as well.While MobileMe might not be the type of storage you're looking for, I highly suggest if you don't have a backup plan in process, get one now! You never know what could happen to your home or studio and of course computers and backup drives aren't perfect and may fail!